HBOT RESEARCH

 

 

​HBOT Mechanism

Bhutani S, Vishwanath G. Hyperbaric oxygen and wound healing. Indian J Plast Surg. 2012;45(2):316–324. doi:10.4103/0970-0358.101309

Thom SR. Hyperbaric oxygen: its mechanisms and efficacy. Plast Reconstr Surg. 2011;127 Suppl 1(Suppl 1):131S–141S. doi:10.1097/PRS.0b013e3181fbe2bf

Thom SR. Oxidative stress is fundamental to hyperbaric oxygen therapy. J Appl Physiol (1985). 2009;106(3):988–995. doi:10.1152/japplphysiol.91004.2008

Wingelaar TT, Brinkman P, van Ooij PJAM, et al. Markers of Pulmonary Oxygen Toxicity in Hyperbaric Oxygen Therapy Using Exhaled Breath Analysis. Front Physiol. 2019;10:475. Published 2019 Apr 24. doi:10.3389/fphys.2019.00475

A.L. Gill, C.N.A. Bell, Hyperbaric oxygen: its uses, mechanisms of action and outcomes, QJM: An International Journal of Medicine, Volume 97, Issue 7, July 2004, Pages 385–395, https://doi.org/10.1093/qjmed/hch074

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HBOT and General Health

Fife CE, Eckert KA, Carter MJ. An update on the appropriate role for hyperbaric oxygen: indications and evidence. Plast Reconstr Surg. 2016;138(3 Suppl):107S–16S. doi:10.1097/PRS.0000000000002714

Thom SR. Oxidative stress is fundamental to hyperbaric oxygen therapy. J Appl Physiol (1985). 2009;106(3):988–995. doi:10.1152/japplphysiol.91004.2008

Fujita N, Ono M, Tomioka T, et al. Effects of hyperbaric oxygen at 1.25 atmospheres absolute with normal air on macrophage number and infiltration during rat skeletal muscle regeneration. PLoS One. 2014;9(12):e115685. Published 2014 Dec 22. doi:10.1371/journal.pone.0115685

Vadas D, Kalichman L, Hadanny A, et al. Hyperbaric oxygen environment can enhance brain activity and multitasking performance. Front Integr Neurosci. 2017;11:25. Published 2017 Sep 27. doi:10.3389/fnint.2017.00025

Hink J, Jansen E. Are superoxide and/or hydrogen peroxide responsible for some of the beneficial effects of hyperbaric oxygen therapy? Med. Hypotheses, 57 (6) (2001), pp. 764-769.

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HBOT and Dementia/Alzheimer’s

Harch PG, Fogarty EF. Hyperbaric oxygen therapy for Alzheimer’s dementia with positron emission tomography imaging: a case report. Med Gas Res. 2019;8(4):181–184. Published 2019 Jan 9. doi:10.4103/2045-9912.248271

Shapira R, Efrati S, Ashery U. Hyperbaric oxygen therapy as a new approach for Alzheimer’s disease. Neural Regen Res. 2018;13(5):817–818. doi:10.4103/1673-5374.232475

Qiang, Li Lan, Xiong Su-qin, Yan Yu-fen, Li Dan, Yan Na-na, Chen Hong-ping, Liu You-ping, Meta-Analysis on the Efficacy and Safety of Hyperbaric Oxygen as Adjunctive Therapy for Vascular Dementia, Frontiers in Aging Neuroscience, VOLUME.11.2019 PAGES=86 DOI=10.3389/fnagi.2019.00086 ISSN=1663-4365

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HBOT and Fibromyalgia

Efrati S, Golan H, Bechor Y, et al. Hyperbaric oxygen therapy can diminish fibromyalgia syndrome–prospective clinical trial. PLoS One. 2015;10(5):e0127012. Published 2015 May 26. doi:10.1371/journal.pone.0127012

Hadanny A, Bechor Y, Catalogna M, et al. Hyperbaric oxygen therapy can induce neuroplasticity and significant clinical improvement in patients suffering from fibromyalgia with a history of childhood sexual abuse-randomized controlled trial. Front Psychol. 2018;9:2495. Published 2018 Dec 17. doi:10.3389/fpsyg.2018.02495

Efrati S, Hadanny A, Daphna-Tekoah S, et al. Recovery of repressed memories in fibromyalgia patients managed with hyperbaric oxygen – case series presentation and suggested bio-psycho-social mechanism. Front Psychol. 2018;9:848. Published 2018 May 29. doi:10.3389/fpsyg.2018.00848

Yildiz S, Kiralp MZ, Akin A, et al. A new modality for fibromyalgia syndrome: hyperbaric oxygen therapy J. Int. Med. Res., 32 (3) (2004), pp. 263-267

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HBOT and Autism

Rossignol DA, Bradstreet JJ, Van Dyke K, et al. Hyperbaric oxygen in autism spectrum disorders. Med Gas Res. 2012;2(1):16. Published 2012 Jun 15. doi:10.1186/2045-9912-2-16

Rossignol DA, Rossignol LW, Smith S, et al. Hyperbaric for children with autism: a multicenter, randomized, double-blind, controlled trial [published correction appears in BMC Pediatr. 2012 Dec;42(4):236]. BMC Pediatr. 2009;9:21. Published 2009 Mar 13. doi:10.1186/1471-2431-9-21

Xiong T, Chen H, Luo R, et al. Hyperbaric oxygen therapy for people with autism spectrum disorder (ASD). Cochrane Database Syst Rev. 2016;10(10):CD010922. Published 2016 Oct 13. doi:10.1002/14651858.CD010922.pub2

Rossignol DA, Bradstreet JJ, Van Dyke K, et al. Hyperbaric oxygen in autism spectrum disorders. Med Gas Res. 2012;2(1):16. Published 2012 Jun 15. doi:10.1186/2045-9912-2-16

Rossignol DA, Rossignol LW. Hyperbaric oxygen therapy may improve symptoms in autistic children. Medical Hypotheses, Volume 67, Issue 2, 2006, Pages 216-228, ISSN 0306-9877, https://doi.org/10.1016/j.mehy.2006.02.009.

Rossignol DA, Frye RE. Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism. Frontiers in Physiology. 5  2014.pgs.150. https://www.frontiersin.org/article/10.3389/fphys.2014.00150 DOI=10.3389/fphys.2014.00150  

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HBOT and Infection

Çimşit M, Uzun G, & Yıldız S (2009) Hyperbaric oxygen therapy as an anti-infective agent. Expert Review of Anti-infective Therapy, 7:8, 1015-1026, DOI: 10.1586/eri.09.76

Ezra N, Dang K, Heuser G. Improvement of attention span and reaction time with hyperbaric oxygen in patients with toxic injury due to mold exposure. Eur J Clin Microbiol Infect Dis. 2011;30(1):1–6. doi:10.1007/s10096-010-0937-8

Mader JT, Brown GL, Guckian JC, et al. A mechanism for the amelioration by hyperbaric oxygen of experimental staphylococcal osteomyelitis in rabbits. J Infect Dis. 1980 Dec. 142(6):915-22

Delasotta LA, Hanflik A, Bicking G, et al. Hyperbaric oxygen for osteomyelitis in a compromised host. Open Orthop J. 2013;7:114–117. Published 2013 May 3. doi:10.2174/1874325001307010114

Ciofu O, Tolker-Nielsen T. Tolerance and resistance of Pseudomonas aeruginosa biofilms to antimicrobial agents-how P. aeruginosa can escape antibiotics. Front Microbiol. 2019;10:913. Published 2019 May 3. doi:10.3389/fmicb.2019.00913

Kolpen M, Lerche CJ, Kragh KN, et al. Hyperbaric oxygen sensitizes anoxic pseudomonas aeruginosa biofilm to ciprofloxacin. Antimicrob Agents Chemother. 2017;61(11):e01024-17. Published 2017 Oct 24. doi:10.1128/AAC.01024-17

Gade PAV, Olsen TB, Jensen PØ, et al. Modelling of ciprofloxacin killing enhanced by hyperbaric oxygen in Pseudomonas aeruginosa PAO1 biofilms. PLoS ONE (2018): e0198909. https://doi.org/10.1371/journal.pone.0198909

Memar MY, Yekani M, Alizadeh N, et al. Hyperbaric oxygen therapy: antimicrobial mechanisms and clinical application for infections. Biomedicine & Pharmacotherapy, Volume 109, 2019, Pages 440-447, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2018.10.142.

Kaye D. Effect of hyperbaric oxygen on Clostridia in vitro and in vivo. Proc Soc Exp Biol Med 1967; 124:360.

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HBOT and Cancer (and Keto)

İyikesici M, Slocum A, Slocum A, et al. (July 07, 2017) Efficacy of Metabolically Supported Chemotherapy Combined with Ketogenic Diet, Hyperthermia, and Hyperbaric Oxygen Therapy for Stage IV TripleNegative Breast Cancer. Cureus 9(7): e1445. DOI 10.7759/cureus.1445

Poff AM, Ari C, Seyfried TN, et al. (2013) The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer. PLoS ONE 8(6): e65522. https://doi.org/10.1371/journal.pone.0065522

Seyfried, TN, Mukherjee, P. Nutr Metab (Lond) (2005) 2: 30. https://doi.org/10.1186/1743-7075-2-30

Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science. 2009;324(5930):1029–1033. doi:10.1126/science.1160809

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Cancer (HBOT Only)

Moen I, Stuhr LE. Hyperbaric oxygen therapy and cancer–a review. Target Oncol. 2012;7(4):233–242. doi:10.1007/s11523-012-0233-x

Thom SR, Bhopale VM, Yang M. Microparticle-induced vascular injury in mice following decompression is inhibited by hyperbaric oxygen: effects on microparticles and interleukin-1.

Journal of Applied Physiology, Volume 126, 2019

Niezgoda JA, Serena TE, Carter MJ.  Outcomes of radiation injuries using hyperbaric oxygen therapy: an observational cohort study. Adv Skin Wound Care, 29 (2016), pp. 12-1

Stępień K, Ostrowski RP, Matyja E. Hyperbaric oxygen as an adjunctive therapy in managed of malignancies, including brain tumours. Med Oncol. 2016;33(9):101. doi:10.1007/s12032-016-0814-0

Oscarsson N, Ny L, Mölne J, Lind F, et al. Hyperbaric oxygen reverses radiation induced pro-fibrotic and oxidative stress responses in a rat model. Free Radic Biol Med. 2017 Feb; 103:248-255. Epub 2016 Dec 27

Zembrzuska K, Ostrowski RP, Matyja E. Hyperbaric oxygen increases glioma cell sensitivity to antitumor with a novel isothiourea derivative in vitro. Oncol Rep. 2019;41(5):2703–2716. doi:10.3892/or.2019.7064

Lu QZ, Li X, Ouyang J, et al. Further application of hyperbaric oxygen in prostate cancer. Med Gas Res. 2019;8(4):167–171. Published 2019 Jan 9. doi:10.4103/2045-9912.248268

Wang YG, Long J, Shao DC, et al. Hyperbaric oxygen inhibits production of CD3+ T cells in the thymus and facilitates malignant glioma cell growth. J Int Med Res. 2018;46(7):2780–2791. doi:10.1177/0300060518767796

Choudhury R. Hypoxia and hyperbaric oxygen therapy: a review. Int J Gen Med. 2018;11:431–442. Published 2018 Nov 20. doi:10.2147/IJGM.S172460

Yahara K, Ohguri T, Udono H, et al. Radiotherapy using IMRT boosts after hyperbaric oxygen therapy with chemotherapy for glioblastoma. J Radiat Res. 2017;58(3):351–356. doi:10.1093/jrr/rrw105

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HBOT and Wound Healing

Health Quality Ontario. Hyperbaric oxygen therapy for the management of diabetic foot ulcers: a health technology assessment. Ont Health Technol Assess Ser. 2017;17(5):1–142. Published 2017 May 12.

Bhutani S, Vishwanath G. Hyperbaric oxygen and wound healing. Indian J Plast Surg. 2012;45(2):316–324. doi:10.4103/0970-0358.101309

Hou S, Wu G, Liang J, et al. Hyperbaric oxygen on rehabilitation of brain tumors after surgery and effects on TNF-α and IL-6 levels. Oncol Lett. 2019;17(3):3277–3282. doi:10.3892/ol.2019.10000

Perren S, Gatt A, Papanas N, et al. Hyperbaric oxygen therapy in ischaemic foot ulcers in type 2 diabetes: a clinical trial. Open Cardiovasc Med J. 2018;12:80–85. Published 2018 Aug 31. doi:10.2174/1874192401812010080

Eskes AM, Ubbink DT, Lubbers MJ, et al. Hyperbaric oxygen therapy: solution for difficult to heal acute wounds? Systematic review. World J Surg. 2011;35(3):535–542. doi:10.1007/s00268-010-0923-4

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HBOT and TBI/Concussion

Boussi-Gross R, Golan H, Fishlev G, et al. Hyperbaric oxygen therapy can improve post concussion syndrome years after mild traumatic brain injury – randomized prospective trial. PLoS One. 2013;8(11):e79995. Published 2013 Nov 15. doi:10.1371/journal.pone.0079995 

Tal S, Hadanny A, Sasson E, et al. Hyperbaric oxygen therapy can induce angiogenesis and regeneration of nerve fibers in traumatic brain injury patients. Front Hum Neurosci. 2017;11:508. Published 2017 Oct 19. doi:10.3389/fnhum.2017.00508

Meng XE, Zhang Y, Li N, et al. Hyperbaric oxygen alleviates secondary brain injury after trauma through inhibition of tlr4/nf-κb signaling pathway. Med Sci Monit. 2016;22:284–288. Published 2016 Jan 26. doi:10.12659/msm.894148

Vlodavsky, E. Palzur, M. Feinsod, et al. Evaluation of the apoptosis-related proteins of the BCL-2 family in the traumatic penumbra area of the rat model of cerebral contusion, managed by hyperbaric oxygen therapy: a quantitative immunohistochemical study. Acta Neuropathol., 110 (2) (2005), pp. 120-126

Hadanny A, Abbott S, Suzin G, et al. Effect of hyperbaric oxygen therapy on chronic neurocognitive deficits of post-traumatic brain injury patients: retrospective analysis. BMJ Open. 2018;8(9):e023387. Published 2018 Sep 28. doi:10.1136/bmjopen-2018-023387

Dong Y, Hu XH, Wu T, et al. Effect of hyperbaric oxygenation therapy on post-concussion syndrome [published correction appears in Exp Ther Med. 2018 Dec;16(6):4918]. Exp Ther Med. 2018;16(3):2193–2202. doi:10.3892/etm.2018.6463

Tal S, Hadanny A, Sasson E, et al. Hyperbaric oxygen therapy can induce angiogenesis and regeneration of nerve fibers in traumatic brain injury patients. Front Hum Neurosci. 2017;11:508. Published 2017 Oct 19. doi:10.3389/fnhum.2017.00508

Tsutsumi I, Tsujimoto Y, Takahashi S, et al. Hyperbaric oxygen therapy for persistent post‐concussion syndrome following mild traumatic brain injury. Cochrane Database Syst Rev. 2017;2017(7):CD012727. Published 2017 Jul 16. doi:10.1002/14651858.CD012727

Eve DJ, Steele MR, Sanberg PR, et al. Hyperbaric oxygen therapy as a potential manage for post-traumatic stress disorder associated with traumatic brain injury. Neuropsychiatr Dis Manage. 2016;12:2689–2705. Published 2016 Oct 20. doi:10.2147/NDT.S110126

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HBOT and Stroke

Rosario ER, Kaplan SE, Khonsari S, et al. The effect of hyperbaric oxygen therapy on functional impairments caused by ischemic stroke. Neurol Res Int. 2018;2018:3172679. Published 2018 Oct 9. doi:10.1155/2018/3172679 

Ostrowski RP, Stępień K, Pucko E, Matyja E. The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications. Arch Med Sci. 2017;13(5):1217–1223. doi:10.5114/aoms.2017.65081

Efrati, G. Fishlev, Y. Bechor, et al. Hyperbaric oxygen induces late neuroplasticity in post stroke patients–randomized, prospective trial. PLoS One, 8 (1) (2013

Liska GM, Lippert T, Russo E, et al. A dual role for hyperbaric oxygen in stroke neuroprotection: preconditioning of the brain and stem cells. Cond Med. 2018;1(4):151–166. 

Efrati S, Fishlev G, Bechor Y, et al. Hyperbaric oxygen induces late neuroplasticity in post stroke patients–randomized, prospective trial. PLoS One. ;8(1):e53716. doi:10.1371/journal.pone.0053716

Hadanny A, Efrati S. Oxygen–a limiting factor for brain recovery. Crit Care. 2015;19(1):307. Published 2015 Sep 1. doi:10.1186/s13054-015-1034-2

Hadanny A, Golan H, Fishlev G, et al. Hyperbaric oxygen can induce neuroplasticity and improve cognitive functions of patients suffering from anoxic brain damage. Restor Neurol Neurosci. ;33(4):471–486. doi:10.3233/RNN-150517

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HBOT and Stem Cells

Thom SR, Bhopale VM, Velazquez OC, et al. Stem cell mobilization by hyperbaric oxygen. American Journal of Physiology-Heart and Circulatory Physiology 2006 290:4, H1378-H1386

Oyaizu T, Enomoto M, Yamamoto N, et al. Hyperbaric oxygen reduces inflammation, oxygenates injured muscle, and regenerates skeletal muscle via macrophage and satellite cell activation. Sci Rep. 2018;8(1):1288. Published 2018 Jan 22. doi:10.1038/s41598-018-19670-x

Liska GM, Lippert T, Russo E, et al. A dual role for hyperbaric oxygen in stroke neuroprotection: preconditioning of the brain and stem cells. Cond Med. 2018;1(4):151–166. 

Peña-Villalobos I, Casanova-Maldonado I, Lois P, et al. Hyperbaric oxygen increases stem cell proliferation, angiogenesis and wound-healing ability of WJ-MSCs in diabetic mice. Front Physiol. 2018;9:995. Published 2018 Jul 30. doi:10.3389/fphys.2018.00995

Fosen KM, Thom SR. Hyperbaric oxygen, vasculogenic stem cells, and wound healing. Antioxid Redox Signal. 2014;21(11):1634–1647. doi:10.1089/ars.2014.5940

Milovanova TN, Bhopale VM, Sorokina EM, et al. Hyperbaric oxygen stimulates vasculogenic stem cell growth and differentiation in vivo. J Appl Physiol (1985). 2009;106(2):711–728. doi:10.1152/japplphysiol.91054.2008

MacLaughlin KJ, Barton GP, Braun RK, Eldridge MW. Effect of intermittent hyperoxia on stem cell mobilization and cytokine expression. Med Gas Res. 2019;9(3):139–144. doi:10.4103/2045-9912.266989

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HBOT and PTSD

Eve DJ, Steele MR, Sanberg PR, et al. Hyperbaric oxygen therapy as a potential manage for post-traumatic stress disorder associated with traumatic brain injury. Neuropsychiatr Dis Manage. 2016;12:2689–2705. Published 2016 Oct 20.doi:10.2147/NDT.S110126

Harch PG, Andrews SR, Fogarty EF, et al. Case control study: hyperbaric oxygen manage of mild traumatic brain injury persistent post-concussion syndrome and post-traumatic stress disorder. Med Gas Res. 2017;7(3):156–174. Published 2017 Oct 17. doi:10.4103/2045-9912.215745

He H, Li X, He Y. Hyperbaric oxygen therapy attenuates neuronal apoptosis induced by traumatic brain injury via Akt/GSK3β/β-catenin pathway. Neuropsychiatr Dis Manage. 2019;15:369–374. Published 2019 Jan 25. doi:10.2147/NDT.S183632

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HBOT and Other Neurological Issues

Nazario J, Kuffler DP. Hyperbaric oxygen therapy and promoting neurological recovery following nerve trauma. Undersea Hyperb Med. 2011 Sep-Oct;38(5):345-66. Review. PubMed PMID: 22013761

Hu Q, Manaenko A, Xu T, et al. Hyperbaric oxygen therapy for traumatic brain injury: bench-to-bedside. Med Gas Res. 2016;6(2):102–110. Published 2016 Jul 11. doi:10.4103/2045-9912.184720

Taghizadeh Asl M, Nemati R, Chabi N, et al. Brain perfusion imaging with voxel-based analysis in secondary progressive multiple sclerosis patients with a moderate to severe stage of disease: a boon for the workforce. BMC Neurol. 2016;16:79. Published 2016 May 26. doi:10.1186/s12883-016-0605-4

M.Z. Kiralp, Ş Yildiz, D. Vural, et al. Effectiveness of hyperbaric oxygen therapy in the manage of complex regional pain syndrome. J. Int. Med. Res., 32 (3) (2004), pp. 258-262.

Oroglu B, Turker T, Aktas S, et al. Effect of hyperbaric oxygen therapy on tense repair of the peripheral nerves. Undersea Hyperb Med. 2011 Sep-Oct; 38(5): 367–373.

Hadanny A, Efrati S. Oxygen–a limiting factor for brain recovery. Crit Care. 2015;19(1):307. Published 2015 Sep 1. doi:10.1186/s13054-015-1034-2

Vadas D, Kalichman L, Hadanny A, et al. Hyperbaric oxygen environment can enhance brain activity and multitasking performance. Front Integr Neurosci. 2017;11:25. Published 2017 Sep 27. doi:10.3389/fnint.2017.00025

Hadanny A, Maliar A, Fishlev G, et al. Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen. Clin Ophthalmol. 2016;11:115–125. Published 2016 Dec 29. doi:10.2147/OPTH.S121307

Tal S, Hadanny A, Sasson E, et al. Hyperbaric oxygen therapy can induce angiogenesis and regeneration of nerve fibers in traumatic brain injury patients. Front Hum Neurosci. 2017;11:508. Published 2017 Oct 19. doi:10.3389/fnhum.2017.00508

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HBOT and Pain-Inflammation

Meng XE, Zhang Y, Li N, et al. Hyperbaric oxygen alleviates secondary brain injury after trauma through inhibition of TLR4/NF-κB signaling pathway. Med Sci Monit. 2016;22:284–288. Published 2016 Jan 26. doi:10.12659/msm.894148

Dulai PS, Gleeson MW, Taylor D, et al. (2014), Systematic review: the safety and efficacy of hyperbaric oxygen therapy for inflammatory bowel disease. Aliment Pharmacol Ther, 39: 1266-1275. doi:10.1111/apt.12753

Hui J, Zhang ZJ, Zhang X, et al. Repetitive hyperbaric oxygen manage attenuates complete Freund’s adjuvant-induced pain and reduces glia-mediated neuroinflammation in the spinal cord, J. Pain, 14 (7) (2013), pp. 747-758

Li F, Fang L, Huang S, et al. Hyperbaric oxygenation therapy alleviates chronic constrictive injury-induced neuropathic pain and reduces tumor necrosis factor-alpha production. Anesth. Analg., 113 (3) (2011), pp. 626-633

Choudhury R. Hypoxia and hyperbaric oxygen therapy: a review. Int J Gen Med. 2018;11:431–442. Published 2018 Nov 20. doi:10.2147/IJGM.S172460

He H, Li X, He Y. Hyperbaric oxygen therapy attenuates neuronal apoptosis induced by traumatic brain injury via Akt/GSK3β/β-catenin pathway. Neuropsychiatr Dis Manage. 2019;15:369–374. Published 2019 Jan 25. doi:10.2147/NDT.S183632

Wu HH, Huang CC, Chang CP, et al. Heat shock protein 70 (HSP70) reduces hepatic inflammatory and oxidative damage in a rat model of liver ischemia/reperfusion injury with hyperbaric oxygen preconditioning. Med Sci Monit. 2018;24:8096–8104. Published 2018 Nov 12. doi:10.12659/MSM.911641

Thompson CD, Uhelski ML, Wilson JR, et al. Hyperbaric oxygen manage decreases pain in two nerve injury models. Neurosci. Res., 66 (3) (2010), pp. 279-283

Oyaizu T, Enomoto M, Yamamoto N, et al. Hyperbaric oxygen reduces inflammation, oxygenates injured muscle, and regenerates skeletal muscle via macrophage and satellite cell activation. Sci Rep. 2018;8(1):1288. Published 2018 Jan 22. doi:10.1038/s41598-018-19670-x

Zhao BS, Meng LX, Ding YY, et al. Hyperbaric oxygen manage produces an antinociceptive response phase and inhibits astrocyte activation and inflammatory response in a rat model of neuropathic pain. J. Mol. Neurosci., 53 (2) (2014), pp. 251-261

Novak S, Drenjancevic I, Vukovic R, et al. Anti-inflammatory effects of hyperbaric oxygenation during DSS-induced colitis in BALB/c mice include changes in gene expression of HIF-1α, proinflammatory cytokines, and antioxidative enzymes. Mediators Inflamm. 2016;2016:7141430. doi:10.1155/2016/7141430

Hou S, Wu G, Liang J, et al. Hyperbaric oxygen on rehabilitation of brain tumors after surgery and effects on TNF-α and IL-6 levels. Oncol Lett. 2019;17(3):3277–3282. doi:10.3892/ol.2019.10000

Di Sabato F, Rocco M, Martelletti P, et al. Hyperbaric oxygen in chronic cluster headaches: influence on serotonergic pathways. Undersea Hyperb. Med., 24 (2) (1997), pp. 117-122

Bennett MH, French C, Schnabel A, et al. Normobaric and hyperbaric oxygen therapy for migraine and cluster headache. Cochrane Database Syst. Rev. (3)(2008). 

Fosen KM, Thom SR. Hyperbaric oxygen, vasculogenic stem cells, and wound healing. Antioxid Redox Signal. 2014;21(11):1634–1647. doi:10.1089/ars.2014.5940

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HBOT and Mitochondria

Palzur E, Zaaroor M, Vlodavsky E, et al. Neuroprotective effect of hyperbaric oxygen therapy in brain injury is mediated by preservation of mitochondrial membrane properties. Brain Res., 1221 (2008), pp. 126-133

K.R. Dave, R. Prado, R. Busto, A.P. Raval, W.G. Bradley, D. Torbati, M.A. Pérez-pinzón,

Hyperbaric oxygen therapy protects against mitochondrial dysfunction and delays onset of motor neuron disease in wobbler mice, Neuroscience, Volume 120, Issue 1, 2003, Pages 113-120,

ISSN 0306-4522, https://doi.org/10.1016/S0306-4522(03)00244-6.

Meyer JN, Hartman JH, Mello DF. Mitochondrial toxicity. Toxicological Sciences, Volume 162, Issue 1, March 2018, Pages 15–23.

Meyer JN, Leung MC, Rooney JP, et al. Mitochondria as a target of environmental toxicants. Toxicol Sci. 2013;134(1):1–17. doi:10.1093/toxsci/kft102

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HBOT and Microbiome

Schmidt TM, Kao JY. A little O2 may go a long way in structuring the GI microbiome. Gastroenterology. 2014;147(5):956–959. doi:10.1053/j.gastro.2014.09.025

Nyabanga CT, Kulkarni G, Shen B. Hyperbaric oxygen therapy for chronic antibiotic-refractory ischemic pouchitis. Gastroenterology Report, Volume 5, Issue 4, November 2017, Pages 320–321, https://doi.org/10.1093/gastro/gov038

Albenberg L, Esipova TV, Judge CP, et al. Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota. Gastroenterology, Volume 147, Issue 5,2014,Pages 1055-1063.e8,ISSN 0016-5085, https://doi.org/10.1053/j.gastro.2014.07.020.

Crabbé A, Jensen PO, Bjarnsholt T, et al. Antimicrobial tolerance and metabolic adaptations in microbial biofilms. Trends in Microbiology. Volume 27, Issue 10, 2019, Pages 850-863, ISSN 0966-842X, https://doi.org/10.1016/j.tim.2019.05.003.

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https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0065522

M A, Ummer VS, Maiya AG, et al. Low level laser therapy for the patients with painful diabetic peripheral neuropathy – A systematic review, Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 10.1016/j.dsx.2019.07.035, (2019).

Wang EB, Kaur R, Fierro M, et al. Safety and penetration of light into the brain. Photobiomodulation in the Brain, 10.1016/B978-0-12-815305-5.00005-1, (49-66), (2019).

Mitochondrial oxidative phosphorylation defect in the heart of subjects with coronary artery disease. Ait-Aissa K, Blaszak SC, Beutner G, et al. Sci Rep. 2019 May 20; 9(1):7623. Epub 2019 May 20.

Jang S, Lewis TS, Powers C, et al. Elucidating mitochondrial electron transport chain supercomplexes in the heart during ischemia-reperfusion. Antioxid Redox Signal. 2017 Jul 1; 27(1):57-69. Epub 2016 Nov 11

Pahwa R, Jialal I. Chronic inflammation. [Updated 2019 Jun 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK493173/

Alberts B, Johnson A, Lewis J, et al. Molecular biology of the cell. 4th edition. New York: Garland Science; 2002. Electron-Transport Chains and Their Proton Pumps. Available from: https://www.ncbi.nlm.nih.gov/books/NBK26904/

Sharma S, Kelly TK, Jones PA. Epigenetics in cancer. Carcinogenesis. 2010;31(1):27–36. doi:10.1093/carcin/bgp220

Gauldie J. Inflammation and the aging process: devil or angel. Nutr Rev. 2007 Dec; 65(12 Pt 2):S167-9.

Hillary RF, Stevenson AJ, Cox SR, et al. An epigenetic predictor of death captures multi-modal measures of brain health. Mol Psychiatry. 2019 Dec 3; Epub 2019 Dec 3.

Banszerus VL, Vetter VM, Salewsky B, et al. Exploring the relationship of relative telomere length and the epigenetic clock in the lipid cardio cohort. Int J Mol Sci. 2019 Jun 21; 20(12). Epub 2019 Jun 21.

Sullivan J, Mirbahai L, Lord JM. Major trauma and acceleration of the ageing process. Ageing Res Rev. 2018 Dec; 48:32-39. Epub 2018 Oct 11.

Mendelsohn AR, Larrick JW. Epigenetic Drift Is a Determinant of Mammalian Lifespan. Rejuvenation Res. 2017 Oct; 20(5):430-436.

Harch, PG. Hyperbaric oxygen in chronic traumatic brain injury: oxygen, pressure, and gene therapy. Med Gas Res 5, 9 (2015) doi:10.1186/s13618-015-0030-6

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Brain research:​

Post Stroke – TBI – Concussion

• Efrati S, Fishlev G, Bechor Y, Volkov O, Bergan J, Kliakhandler K, et al. (2013) Hyperbaric Oxygen Induces Late Neuroplasticity in Post Stroke Patients – Randomized, Prospective Trial. PLoS ONE 8(1): e53716. https://doi.org/10.1371/journal.pone.0053716

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0053716

• Boussi-Gross R, Golan H, Fishlev G, Bechor Y, Volkov O, Bergan J, et al. (2013) Hyperbaric Oxygen Therapy Can Improve Post Concussion Syndrome Years after Mild Traumatic Brain Injury – Randomized Prospective Trial. PLoS ONE 8(11): e79995. https://doi.org/10.1371/journal.pone.0079995

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079995

• Neurol Res Int. 2018 Oct 9;2018:3172679. doi: 10.1155/2018/3172679. eCollection 2018.

https://www.ncbi.nlm.nih.gov/m/pubmed/30402285/

• Boussi-Gross, R., Golan, H., Volkov, O., Bechor, Y., Hoofien, D., Schnaider Beeri, M., Ben-Jacob, E., & Efrati, S. (2014, November 10). Improvement of Memory Impairments in Poststroke Patients by Hyperbaric Oxygen Therapy. Neuropsychology. Advance online publication. http://dx.doi.org/10.1037/neu0000149

http://www.assafh.org/clinic/Hifrbaric/Documents/ASAF836%20EFRATI%208.12.2014.pdf

• Neuroimmunomodulation. 2016;23(2):122-9. doi: 10.1159/000445689. Epub 2016 May 24.​

 

Cerebral Palsy

• Shai Efrati, Eshel Ben-Jacob, UHM 2014, Vol. 41, No. 2 – HBO2 for Manage Of Cerebral Palsy: Editorial perspective How and why hyperbaric oxygen therapy can bring new hope for children suffering from cerebral palsy – An editorial perspective 

http://www.assafh.org/clinic/Hifrbaric/Documents/How%20and%20why%20hyperbaric%20oxygen%20therapy%20can%20bring%20new%20hope%20for%20children%20suffering%20from%20cerebral%20palsy.pdf

http://www.assafh.org/clinic/Hifrbaric/Documents/Intensive%20rehabilitation%20combined%20with%20HBO2%20therapy%20in%20children%20with%20cerebral%20palsy_A%20controlled%20longitudinal%20study%202014.pdf

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Brain Metabolism

• Front Integr Neurosci. 2017 Sep 27;11:25. doi: 10.3389/fnint.2017.00025. eCollection 2017.

https://www.ncbi.nlm.nih.gov/m/pubmed/29021747/

http://www.assafh.org/sites/en/clinic/Hifrbaric/Documents/Oxygen%20-%20a%20limiting%20factor%20for%20brain%20recovery.pdf

• XinwangYingabWenzhanTuabSisiLiabQiaoyunWuabXiaolongChenabYeZhouabJieHuabGuanhuYangbSongheJiangab, Hyperbaric oxygen therapy reduces apoptosis and dendritic/synaptic degeneration via the BDNF/TrkB signaling pathways in SCI rats. Life Sciences, Volume 229, 15 July 2019, Pages 187-199

https://www.sciencedirect.com/science/article/abs/pii/S0024320519303753?via%3Dihub

• Med Gas Res. 2019 Jan 9;8(4):181-184. doi: 10.4103/2045-9912.248271. eCollection 2018 Oct-Dec.

https://www.ncbi.nlm.nih.gov/m/pubmed/30713673

• PLoS One. 2017 May 23;12(5):e0178182. doi: 10.1371/journal.pone.0178182. eCollection 2017.

https://www.ncbi.nlm.nih.gov/m/pubmed/28542481

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Autoimmune – Inflammation

• Clin Exp Rheumatol. 2019 Jan-Feb;37 Suppl 116(1):81-89. Epub 2019 Feb 8.

https://www.ncbi.nlm.nih.gov/m/pubmed/30747094

• J. Hui, Z.J. Zhang, X. Zhang, Y. Shen, Y.J. Gao Repetitive hyperbaric oxygen manage attenuates complete Freund’s adjuvant-induced pain and reduces glia-mediated neuroinflammation in the spinal cord J. Pain, 14 (7) (2013), pp. 747-758

• Efrati S, Golan H, Bechor Y, Faran Y, Daphna-Tekoah S, Sekler G, et al. (2015) Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome – Prospective Clinical Trial. PLoS ONE 10(5): e0127012. https://doi.org/10.1371/journal.pone.0127012

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127012